In multicellular organisms each differentiated cell functions in a specialized way as part of a coherent larger system that evolved as a whole. That is, the specializations coevolved together. One specialization supports and depends upon another. All cells participate in all four architectural realms at once.Specialization - All healthy Metazoan cells are specialized. Even adult stem cells are somewhat specialized. What is perhaps the most specialized aspect of the cells, other than their unique shape and function, is their unique repertoire of message receptors that determine the set of message molecules to which they can respond. They all share common behaviors too. Included in the common behavior are participation in the cues and signals of their stigmergy relationship with the rest of the body, and obedience to apoptosis messages. In other words, as multicellular organisms evolved specialized behaviors, they also evolved appropriate messaging, stigmergy and apoptosis behaviors.
Polymorphic Messaging - Complex messenger proteins often act as "bundles" of messages. That is, one messenger protein may have separate domains, each with a different messaging function . And often, the different message domains address each of the other three architectural principles. For example, one domain initiates signal cascades specific to the unique specialized function of that type of cell, another domain on the same complex molecular messenger facilitates or verifies physical attachment to the extracellular matrix (i.e., deals explicitly with the stigmergy structure), and yet another provides signals that either suppress or encourage apoptosis! The existence of these multi-part messages shows not only that the organisms evolved along with the four principles, but also how fundamental these principles are. A single multi-part message speaks to the functional relationship of the cell to the whole organism/tissue/organ rather than to just a single cell function.
Stigmergy - Virtually all cells other than simple red blood cells that lack a nucleus and most organelles are affected by stigmergy cues and/or signals. Even unattached cells such as other blood and lymph born cells are affected by and affect blood borne stigmergy signals, e.g. hormones. Cells that are attached to the Extracellular Matrix (ECM), i.e., the stigmergy structure, leave long-lasting cues (persistent messages) in those structures that affect other cells. In turn, the cells respond to such cues in ways that may cause them to modify the physical structures; that's how the structures are built in the first place. Cells that are normally attached or in direct contact with the ECM require constant feedback from the ECM. Absent the appropriate attachment cues, they suicide (undergo apoptosis).
Not only do cells reflect all four principles at once, the principles themselves are interdependent in the sense that each one relies on the others.
As multicellular computing architectures evolve, especially the emerging Service Oriented Architectures (SOA) and less formal Web Service mashups, we would be wise to adopt and carefully interleave all four principles. Similarly, the architecture of multicellular computing messages should also be fully multicellular. Those who "design" multicellular computing systems (or better put, attempt to grow and evolve such systems), should not only give thought to the various kinds of specialized "cells" that are needed, but also to how those cells implement the four principles and fit into a multicellular message architecture.
In summary, as we develop architectural patterns for the use of each of the four principles in hardware and software, we must ensure that they can be interwoven. We also need to develop a meta-pattern that determines how the interweaving is to happen.
Last revised 3/30/2015